As an interface with the environment, the skin is a complex ecosystem, colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens such [...]

Exposure to MNP generates Th2 response-inducing dendritic cells. Transfer of OVA/MNP-primed dendritic cells induces nasal allergy. Inhibition of Bcl2L12 prevents nasal allergy development [...]

Environmental events in early in life are critical to development of allergic diseases later in life. We found IgE-class-specific immunosuppression in offspring whose mothers had been administered anti-IgE during pregnancy. [...]

We found upregulation of 47 immunoglobulin genes and 22 S. aureus infection-related genes in refractory atopic keratoconjunctivitis tissue by RNA-seq analysis, suggesting that lymphoid neogenesis and stimuli from infection are [...]

This is the first double-blind, placebo-controlled study showing that vaccination with recombinant hypoallergenic allergen-derivatives is safe and induces sustained allergen-specific IgG responses which block allergic patients IgE binding to the [...]

The immune signature in elderly patients with CRS suggests a distinct pathophysiology marked by prevalence of bacterial colonization and an exaggerated but apparently ineffective neutrophilic pro-inflammatory response to microbial pathogens. [...]

This pragmatic, updated assessment of variability among pneumococcal antibody assays suggests that variability may now be greater than previously reported, and potentially influential in clinical decision making. [...]

Mast cells (MC), well known for their effector functions in Th2 skewed allergic and also autoimmune inflammation, become increasingly acknowledged for their role in protection of health. It is now [...]

The “atopic march” recognizes the increased occurrence of asthma and/or allergic rhinitis after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD onset are poorly understood, but may [...]

We identified P2X3 purinoceptors (P2X3Rs) as ligand-gated channels whose activation stimulates a subpopulation of sensory neurons expressing Mas-related G protein-coupled receptor A3 (MrgprA3), linked to itch. P2X3Rs may be targets [...]

This review explores the current status of diagnosis and differential diagnosis, radiographic findings, and diverse antigens causing hypersensitivity pneumonitis with presentation of the complicated immunologic processes and treatment involved. [...]

Incorporating component-resolved allergen diagnosis and peanut conjunctival allergen provocation test in the diagnostic algorithm appears to improve health-related quality of life at an acceptable increase in costs, representing the optimal [...]

The EPX histologic scoring system can be used to differentiate children with EoE and PPI-REE relative to GERD, supporting the relationship between these 2 groups and enhancing current diagnostic and [...]

This case demonstrates successful immune reconstitution following hematopoietic stem cell transplantation in NIK deficiency. [...]

This study shows that local immunereactive and functional/blocking allergen-specific IgG4 antibodies in the nasal fluid are induced following grass pollen SCIT. Moreover, nasal blocking antibodies correlated closely with clinical response [...]

Mild forms of vibratory angioedema/pruritus are more common than expected. As the ADGRE2-mutation causing familiar vibratory angioedema was not seen in the population investigated, at least two subtypes must exist. [...]

Adult asthma remission can be predicted using baseline clinical measurements obtained in early childhood. Persistent childhood asthmatics with normal baseline measurements of airway obstruction, airways responsiveness, and serum eosinophil count [...]